Vice President of the United States of America, Kamala Harris and her husband are expected in town later today as she begins her tour of Africa.
She becomes the fourth top White House official - rank of president - to visit Ghana under the Fourth Republic.
Bill Clinton visited during Jerry John Rawlings era, Kufuor received President George Bush and the last such visit was when Barack Obama, fresh from his 2008 victory chose Ghana as his first African destination on July 10, 2009.
President John Evans Atta Mills, his vice John Dramani Mahama and his two predecessors were present at events during Obama's high-profile and widely celebrated visit.
Obama arrived at the Kotoka International Airport (KIA) whith his wife and two daughters. He later visited the Cape Coast castle and also delivered an address before Parliament.
Read the Ghana News Agency's full report of his arrival
Obama begins historic visit to Ghana
US President Barack Obama arrived in Accra on Friday night to a warm proverbial Ghanaian "Akwaaba" to begin his momentous two-day visit, his first to a sub-Saharan African nation since assuming office.
The US Presidential jet, Air Force One, which is making its third call to the Kotoka International Airport, after President Bill Clinton (1998) and President George W. Bush (2008), touched down around 2105 hours.
Moments later, a brimming President Obama accompanied by his wife Michelle, their two daughters, Malia and Sasha, and a 50-member delegation, came out of the aircraft to euphoric cheers. There were moving scenes at the airport as President John Evans Atta Mills, resplendent in a smock and his wife Naadu, in a wax kaba cloth, approached the gangway to receive the US first family. Nadei Okaikoi, eight-and-half years old class three pupil of ALSYDS Academy, presented a bouquet to President Obama.
The US president and his wife and children, full of smiles, were introduced to the welcoming party which included politicians from across the political divide, including Nana Akufo-Addo, the losing presidential candidate of the New Patriotic Party (NPP).
The festive atmosphere was enhanced by a dancing troupe from the National Dance Company whose Coordinator, Mr George Lamptey, said they were performing heraldic dances meant to welcome the august visitor and his family and make them feel at home.
President Obama savoured the moment by taking a few steps to the "frontonfron" beat and encouraged his wife, who was then walking with Mrs Mills, to join in dancing to the beat.
A large crowd of youth wearing Obama T-shirts defied intermittent showers as they lined parts of the street to the airport to welcome the US President.