Medeama will play Sudanese side Al Ahly Shendi in the round of 16 in the CAF Confederation Cup next month.
The twice Ghanaian FA Cup holders secured passage after beating Libyan side Al Ittihad 2-1 on aggregate.
The Mauve and Yellows recorded an impressive 2-0 win over the North African side at home on Sunday to set up a date against the rich Sudanese side.
The West Africans will travel to Sudan for the first leg tie on the weekend of 8-10 April before the return leg takes place at the Sekondi stadium on April 17.
Al Shendi reached this stage after edging Congolese side Saint Eloi Lupopo 2-2 on the away goal rule.