Agbozome Weavers could become the only third-tier side in the Round of 16 of the MTN FA Cup if they eliminate Asante Kotoko next month.
Both sides will compete for a place in the fourth round when they meet in their outstanding Round of 32 fixture in Ho on April, 3.
And that will complete the list of qualifiers for the next round.
However, it looks a fairly represented table between clubs from the Premier and Division One League.
The Premier League has eight sides who have reached the last 16 with seven clubs from the second-tier league ahead of the draw.
Qualified teams for Round of 16 draw
Amidaus Professionals, Rainbow FC, Guan Stars, Hearts of Oak, Tudu Mighty Jets, Aduana Stars, Medeama SC, Berekum Chelsea, Gold Stars, Heart of Lions, Tema Youth, Nania FC, AshantiGold, Eleven Wise, Starke FC, Agbozome Weavers/Asante Kotoko