Asante Kotoko will face Hearts of Oak in the first semi-final of the GHALCA G8 tournament on Wednesday in Kumasi.
The first Super Clash of the year will be played at the Baba Yara Stadium.
Kotoko emerged winners in Group A after beating Aduana Stars 2-0 on Sunday in their final Group match.
Their perennial rivals managed a topsy-turvy 3-2 win over Ebusua Dwarfs in Cape Coast to finish second in the pool.
The second semi-final will be played at the Cape Coast Stadium between Medeama and Dreams FC.