After having a rest on match day one due to Aduana Stars' involvement in CAF inter-club competition, Liberty Professionals will open their season this weekend.
They come face to face with WAFA SC at the Karl Reindorf park on Sunday.
The Scientific Soccer Lads have been threatened with relegation for the past three seasons.
That's the more reason my they must clinch their first three points on Sunday by beating the Academy lads to cushion them in the quest to avoid such a situation this time.
This is will not come easy for the fact that Liberty Professionals have not beaten WAFA SC in their last four meetings.
Former youth team coach Reginald Asante Boateng has been made the substantive head coach and Sunday's game is his first ever in charge in the elite division.
New additions Richard Yamoah, Alex Ofosu Acheampong and Mohammed Latif are in line for their debuts on Sunday.
WAFA SC have lost all of their last five away matches in the premier league as they prepare to visit to Dansoman to take on the Scientific Soccer Lads looking to take all the points.
Now four matches unbeaten against Liberty Professionals, the Academy boys will target a continuation of that run to get their first victory of the season.
Despite losing the majority of their regulars before the season, WAFA SC have raised a new team who held Asante Kotoko SC to a 1-1 stalemate at the Sogakope park last weekend.
Togolese import Atte Youssifou, Prosper Ahiabor, Francis Boateng, Aminu Mohammed and Justice Amate Aaron were all given starting roles against the Porcupine Warriors last Sunday.
These lads are expected to keep their places in the weekend's fixture as Adam Inusah is likely to return.
Central defender Abukari Ibrahim remains out with an injury. MATCH FACTS
Head To Head
Total league meetings = 12
Liberty Professionals wins = 5
Drawn matches = 2
WAFA SC wins = 5
~ Liberty Professionals have suffered only one loss in their last five matches in the premier league.
(W4 D0 L1)
~ WAFA SC have recorded just one victory in their last seven fixtures in the premier league.
(W1 D3 L3)
~ Liberty Professionals have lost just once in their last seven home league games. They have won all of the last four.
(W5 D1 L1)
~ WAFA SC are winless in their last nine away games in the premiership. All of the last five have been defeats.
(W0 D2 L7)
~ Liberty Professionals have lost just two of their six home meetings with WAFA SC in the premier league.
(W2 D2 L2)
~ WAFA SC are unbeaten in their last four premier league matches against Liberty Professionals.
(W2 D2 L0)
~ Liberty Professionals have conceded in all of their last five home games in the premier league.
~ WAFA SC have kept only two clean sheets out of their last ten premiership games on the road.