An aircraft carrying Malawi's Vice-President Saulos Chilima and nine others has gone missing, a statement from the president's office has said.
The Malawi Defence Force aircraft "went off the radar" after it left the capital, Lilongwe, on Monday morning, it added.
The president ordered a search and rescue operation after aviation officials were unable to contact the aircraft.
It was supposed to land at Mzuzu International Airport, in the country’s north, just after 10:00 local time (11:00 BST).
After being informed of the incident, Malawi's President Lazarus Chakwera cancelled his scheduled flight to the Bahamas.