The Egyptian Football Association has launched an investigation into the whereabouts of the trophy for the Africa Cup of Nations.
Its absence was discovered during work on a small museum at the association's headquarters in Cairo.
Egypt has won the Africa Cup of Nations three times in a row - in 2006, 2008 and 2010 - after which it was granted the right to keep the trophy for good.
Angry fans stormed the building in 2013 but it is not clear if that is when the trophy disappeared.