Defending champions Ahly host Ghana's Asante Kotoko in the other Group A game on Saturday.
The Egyptian club's quest to successfully defend their title has been buoyed by the return from injury of key midfielder Mohammed Aboutrika.
Ahly and Kotoko are equal on four points in second place but Ahly are fancied to win the crucial game in Cairo.
Tunisia's CS Sfaxien of Tunisia will edge closer to a semi-final place if they win at home against JS Kabylie of Algeria on Saturday.
GROUP B
Group B leaders ASEC Mimosas need to avoid defeat to Enyimba to keep up their top place.
Sunday's match in Aba presents Enyimba with a chance to avenge a 3-0 defeat to the Ivorians two weeks ago and regain leadership of the group.
In Obuasi, Ghana's Hearts of Oak will be seeking to break their goaldrought against struggling South Africans Orlando Pirates.
Hearts gained their first point of the campaign with a goalless draw in Johannesburg two weeks ago.
After three successive draws, Pirates must win Sunday's Group B game to have any chance of progressing to the semi-finals.