Uruguay are unbeaten in their last six World Cup games, keeping four clean sheets in the process.
After winning three consecutive World Cup matches for the first time since 1954 Uruguay have made it to the quarter-finals for the first time since 1970.
Luis Suarez has now scored as many World Cup goals as Diego Forlan, with three each.
Uruguay have won the last nine games in which they have been leading at half-time.
On the last 22 occasions that Suarez has found the net in all competitions for club and country, he has finished on the winning side.
Luis Suarez has scored 55 goals in 61 appearances for club and country this season.
Asamoah Gyan is only the second African player to score four goals at the World Cup after Roger Milla (who scored five).
Ghana are only the third African side to reach the quarter-finals of the World Cup after Senegal in 2002 and Cameroon in 1990.
All three of Diego Forlan's World Cup goals have come against African nations. Uruguay have scored three goals in both of their two World Cup encounters against African sides.