Dr. Nduom was born in Elmina on Sunday, February 15, 1953. He was given the name Papa Kwesi Nduom by his parents, Mr. Joseph Hubster Yorke and Mrs Monica Yorke. Dr. Nduom was also named Joseph Hubster Yorke Jr. by his parents.

Papa Nduom is a well-known name in the Yorke family. The Yorke family can be found in many towns and villages in Ghana particularly in Elmina, Tarkwa and Gomoa Dago. Mr. Samuel Yorke the grandfather of Dr. Nduom was instrumental in laying the foundation for what has become St. Augustine's College at Cape Coast in the Central Region of Ghana. Dr. Nduom's mother is one of the Mensah-Brown brothers and sisters from Elmina.

Dr. Nduom's grandfather's annual family gatherings that took place in Tarkwa when he was alive, was instrumental in building a foundation for the extended family interaction, community spirit and caring that he exhibits currently.

Dr. Nduom attended the St. Joseph's Catholic Boys School in Elmina and the St. Augustine's Practice School in Cape Coast. In 1966, he entered St. Augustine's College, Cape Coast. In 1970, he won an American Field Service scholarship and spent one year with an American family in Cokato, Minnesota. He obtained a high school diploma from Cokato High School. While in Cokato, he participated in debate, American football, athletics and soccer. He credits the year he spent in Cokato with teaching him the necessity of strong family values.

He returned to St. Augustine's to complete Sixth Form education from 1971 to 1973. In Sixth Form, he won the prize as the best - student. st Augustereo Economics and motivated his interest in economics, business and professionalism. It is during the Sixth Form period that his interest in democracy was awakened by a new arrangement for students to vote for their prefects. Dr. Nduom campaigned hard and was elected the School's Protocol Prefect for the 1972-73 academic year.

Dr. Nduom returned to the USA in August, 1973. He worked his way through the Milwaukee Area Technical College, Marquette University and ended up at the University of Wisconsin where he obtained a BA degree in Economics in December, 1975. He obtained an MS in Management from the School of Business and a Ph.D. in Service Delivery Systems (USI Program) all from the University of Wisconsin. Dr. Nduom's university education was self-funded through jobs in a meat factory, a parking lot, a cannery and an internship with Northwestern Mutual Life Insurance Company, all in Milwaukee, Wisconsin.

Dr. Papa Kwesi Nduom started full-time work after the obtaining his bachelor's degree as a Life Insurance Underwriter with the Northwestern Mutual Life Insurance Company. He changed jobs and worked for Blue Cross Blue Shield of Wisconsin and the Milwaukee Metropolitan Sewerage District before he joined Deloitte & Touche (then Touche Ross) in 1981 as an Associate Consultant. Dr. Nduom moved rapidly through the ranks at Deloitte & Touche and became a Partner of the firm in the Milwaukee office in 1986. Out of over 1000 partners, Dr. Nduom was one of five blacks who were partners in 1986. In 1988, he was transferred to the Washington, DC office of Deloitte & Touche. In 1992, he established Deloitte & Touche, West Africa Consulting after spending two years commuting between Ghana and Washington, DC on various consulting assignments.

The firm he established, was a non-territorial consulting practice that in a very short period of time provided management consulting services to many major national and multi-national companies in the African region.

Within five years of its establishment, the firm had over 80 professionals based in Ghana, Cameroun, Nigeria, Liberia, Cote d'Ivoire and worked in Africa, Middle East and the USA. The major clients of the firm included Ashanti Goldfields Company, African Development Bank, Texaco, Elf Oil, African Reinsurance, Zimbabwe National Social Security Authority, Ghana Telecom, Nestle, Unilever and Malawi Oil Company and others. Dr. Nduom has also served as the Coordinator of Management Consulting for the African Region. Dr. Nduom holds a certificate in Management from Marquette University, a Certificate in Insurance from the Life Office Management Institute in the USA, and is a Certified Management Consultant (CMC) of the Institute of Management Consultants, Washington, DC.